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KMID : 0360220110520091039
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Journal of the Korean Ophthalmological Society
2011 Volume.52 No. 9 p.1039 ~ p.1047
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Two-Year Results of Intravitreal Bevacizumab Injection in Retinal Vein Occlusion
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Lee Young-Seob
Kim Moo-Sang
Yu Seung-Young
Hyung Woo Kwak
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Abstract
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Purpose:The authors evaluated the 2-year clinical results of intravitreal bevacizumab injection in retinal vein occlusion (RVO).
Methods:Thirty-two eyes of 32 patients treated with an intravitreal bevacizumab injection of 1.25 mg (0.05 ml) for RVO (branch RVO: 22 eyes, central RVO: 10 eyes), repeated 3 times at a 6-week interval and were available for a follow-up period of at least 2 years were retrospectively reviewed. Best-corrected visual acuity (BCVA) before treatment and 6, 12, and 24 months after 3 serial injections, was recorded. The optical coherence tomography (OCT) results were analyzed to identify prognostic factors for recurrent macular edema that needed reinjection.
Results:Two years after the treatment, mean BCVA was significantly improved (p = 0.000). Out of 32 eyes, 16 (branch RVO: 8 eyes; central RVO: 8 eyes) needed reinjection because of recurrent macular edema. In central RVO, a significantly high reinjection rate was shown in serous retinal detachment (SRD) compared with cystoid macular edema (CME) as identified in OCT findings (p = 0.049). Additionally, in branch RVO, a high reinjection rate was shown in SRD, although statistically not significant (p = 0.375).
Conclusions:In patients with RVO, a significant visual improvement was maintained for at least 2 years after intravitreal bevacizumab injection. Based on OCT results, SRD showed a high reinjection rate compared with CME in CRVO.
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KEYWORD
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Bevacizumab, Macular edema, OCT results, Retinal vein occlusion, Two-year results
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